Table 1

Performance characteristics of POCT troponin assays8 16 18

Assay	Platform	Company	Concentration at 10% CV	Specimen type	99th percentile	Per cent normals measured ≥LoD	Assay type/device
hs-cTnI	Atellica VTLi	Siemens	NP (20% CV 6.7 ng/L)	Li-heparin plasma	Overall: 23 ng/L F: 18 ng/L M: 27 ng/L	Overall: 83.7% F: 79.7% M: 87.3%	hs; cds
hs-cTnI/cTnI-II	PATHFAST	LSI Medience (formerly Mitsubishi)	15 ng/L	Heparin-Na, heparin-Li or EDTA whole blood or plasma	Overall: 27.9 ng/L F: 20.3 ng/L M: 29.7 ng/L	Overall: 66.3% F: 52.8% M: 78.8%	hs; cds
hs-cTnI	TriageTrue	Quidel/Alere	4.4–8.4 ng/L (plasma) 5.8–6.2 ng/L (whole blood)	EDTA whole blood or plasma	Overall: 20.5 ng/L F: 14.4 ng/L M: 25.7 ng/L	Overall: ≥50%	hs; bls
cTnI test pack	STRATUS CS Acute Care	Siemens	0.06 µg/L	Whole blood (Li or NP heparin) or plasma Li or Na heparin	Overall: 0.07 µg/L		cs; bls
TnI	AQT90 FLEX	Radiometer	0.027 µg/L	EDTA and heparinised whole blood and plasma	Overall: 0.023 µg/L		cs; bls
TnT	AQT90 FLEX	Radiometer	0.026 µg/L	EDTA and heparinised whole blood and plasma	Overall: 0.017 µg/L		cs; bls
Troponin I	RAMP	Response Biomedical	0.21 µg/L	Only EDTA whole blood	Overall: <0.10 µg/L		Non-hs/cs; bls
cTnI	i-STAT	Abbott	0.1 µg/L	Na and Li heparinised whole blood and plasma	Overall: 0.08 µg/L		Non-hs/cs; cds
Cardiac POC troponin T	Cobas h 232	Roche	9.3% between 0.04 and 0.2 µg/L	Heparinised whole blood	NP		Non-hs/cs; cds

Adapted from the International Federation of Clinical Chemistry and Laboratory Medicine—Clinical Applications of Cardiac Bio-Markers Updated tables (https://www.ifcc.org/media/477653/point-of-care-cardiac-troponin-i-and-t-assay-analytical-characteristics-designated-by-manufacturer-v012019.pdf).
bls, bedside use; cds, compact desktop systems; cs, contemporary sensitivity; CV, coefficient of variation; hs-cTnI, high-sensitivity cardiac troponin I; Li, lithium; Na, sodium; NP, not provided; POCT, point-of-care test; TnI, troponin I; TnT, troponin T.