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Timing of antibiotic administration in community-acquired pneumonia
Report by: Yat Sim Jasmine Ng, Visiting Scholar
Search checked by: Colin Graham, Professor of Emergency Medicine
Institution: Accident and Emergency Medicine Academic Unit, The Chinese University of Hong Kong, Hong Kong
Three-part question
In (adult patients presenting to the hospital with suspected community-acquired pneumonia (CAP) requiring admission), does (antibiotic administration within a specific time window) (reduce patient morbidity and mortality)?
Clinical scenario
A 70-year-old lady presents to the emergency department (ED) with 2 days of fever, shortness of breath, and cough productive of green sputum. Chest x-ray confirms right basal pneumonia. She requires oxygen therapy and admission. It is busy in the ED. This patient has been waiting for 3.5 h. Her bed is ready in the ward. You wonder if giving her the antibiotics now would affect her clinical outcome in terms of time to clinical stability, length of hospital stay, and mortality.
Search strategy
Medline 1990 to September week 1 2010 using OVID interface (exp Community-Acquired Infections/OR exp Pneumonia/OR community acquired pneumonia.mp) AND (antibiotics.mp. OR exp Anti-Bacterial Agents/OR antimicrobials.mp) AND (early administration.mp. OR timely …
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