Natural history and course of acquired lactic acidosis in adults☆
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Cited by (151)
Metabolic Acidosis: Differentiating the Causes in the Poisoned Patient
2022, Emergency Medicine Clinics of North AmericaCitation Excerpt :Many clinicians may be inclined to treat toxin-induced metabolic acidosis with a buffer such as sodium bicarbonate to increase serum pH. This practice should be discouraged. The administration of sodium bicarbonate has never been shown to improve outcomes in patients with metabolic acidosis and can be detrimental in some.65 Paradoxic intracellular acidosis can occur due to increased production of carbon dioxide.66
Electronic transport properties of nanoribbons of graphene and ψ-graphene -based lactate nanobiosensor
2020, Superlattices and MicrostructuresIntravenous Sodium Bicarbonate in Treating Patients With Severe Metabolic Acidemia
2019, American Journal of Kidney DiseasesLactate biosensing: The emerging point-of-care and personal health monitoring
2018, Biosensors and BioelectronicsHyperlactatemia in ICU patients: Incidence, causes and associated mortality
2017, Journal of Critical CareLactic Acidosis: Current Treatments and Future Directions
2016, American Journal of Kidney DiseasesCitation Excerpt :Limited data suggest that at a given blood lactate level, acidemia is associated with worse clinical outcomes8,9; however, further work is required on this important issue. Sustained hyperlactatemia in sepsis or low-flow states carries mortality ≥ 60%.1,10 Next, we first provide a brief description of the current therapy of lactic acidosis and then suggest potential future therapies that derive from advances in our understanding of the pathophysiology of the disorder.
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This work was supported by DK 35448 and RR 00082 from the National institutes of Health.