Case Report
Triiodothyronine (T3) toxicosis with hypokalemic periodic paralysis and ventricular tachycardia

https://doi.org/10.1016/S0022-0736(05)80288-2Get rights and content

Abstract

An unusual case of triiodothyronine toxicosis and hypokalemic periodic paralysis presenting with ventricular tachycardia in a young Chinese man is presented. Clinical index of suspicion and approach to medical management are discussed.

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    The endocrinopathy can also cause myocardial changes (e.g., acromegaly) or electrolyte disturbances produced by hormone excess (e.g., hyperkalemia in Addison disease and hypokalemia in Conn syndrome), and certain endocrine disorders can accelerate the progression of conditions such as underlying structural heart disease secondary to dyslipidemia or hypertension, increasing the risk of serious arrhythmias. Thyrotoxicosis commonly causes atrial arrhythmias; cases of VT/SCD are extremely uncommon but may occur with concomitant electrolyte disturbances (530). VT/SCD are more common in hypothyroidism, the basic underlying mechanism being possibly related to prolongation of the QT interval (531,532).

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