Clinical Versus Statistical Significance in the Assessment of Pain Relief☆,☆☆,★
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2021, Journal of Emergency MedicineA Randomized Trial Comparing the Efficacy of Five Oral Analgesics for Treatment of Acute Musculoskeletal Extremity Pain in the Emergency Department
2021, Annals of Emergency MedicineCitation Excerpt :The following parameters were used to calculate the sample size: an overall 2-sided significance level of .05, 80% power, and a Δ of 1.3-NRS-unit change in pain between groups. This value was based on a validated and reliable standard definition of the minimal clinically significant difference in pain between different analgesic treatments.14 A within-group SD of 2.6 was used to calculate the sample size, based on estimates from previous work of variability of change in pain in response to oral opioid analgesics.15,16
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From the Division of Emergency Medicine, Emory University School of Medicine, and the Rollins School of Public Health, Emory University, Atlanta, Georgia.
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Address for reprints: Knox H Todd, MD, MPH, Center for Injury Control, Rollins School of Public Health, Emory University, 1518 Clifton Road Northeast, Room 254, Atlanta, Georgia 30322, Fax 404-727-8744
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Reprint no. 47/1/72436