Clinical research: heart failure
Brain natriuretic peptide and n-terminal brain natriuretic peptide in the diagnosis of heart failure in patients with acute shortness of breath

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Abstract

Objectives

This study sought to compare the utility of measurement of plasma brain natriuretic peptide (BNP) and N-terminal brain natriuretic peptide (N-BNP) in the diagnosis of heart failure (HF) in patients with acute dyspnea.

Background

Plasma BNP is useful in differentiating HF from other causes of dyspnea in the emergency department. The N-terminal component of BNP has a longer half-life, and in HF increases in plasma N-BNP are proportionately greater.

Methods

We studied 205 patients (average age 70 ± 14 years) presenting to the emergency department with acute dyspnea. Brain natriuretic peptide was analyzed using a point-of-care test and two locally developed radioimmunoassays. N-terminal BNP was measured using a locally developed radioimmunoassay and a commercially available assay. Final diagnosis of HF was adjudicated by two cardiologists.

Results

Patients with HF (n = 70) had higher mean levels of both hormones by all assays (p < 0.001 for all). Results with all assays correlated closely (r values between 0.902 and 0.969). Subjects with left ventricular (LV) dysfunction or left-sided valvular disease but no HF had intermediate levels of BNP and N-BNP (lower than subjects with HF, and higher than subjects without HF with no LV dysfunction or left-sided valvular disease) (p < 0.01 for all). Using optimum cut-offs, specificity for the diagnosis of HF ranged between 70% and 89% (highest for the N-BNP assays). Sensitivity ranged between 80% and 94% (highest for the point-of-care BNP assay).

Conclusions

Measurement of BNP or N-BNP is useful in the diagnosis of HF in acute dyspnea. Commercially available assays compare favorably with well-validated laboratory assays. Differences in sensitivity and specificity may influence the assay choice in this setting.

Abbreviations

BNP
brain natriuretic peptide
CNP
C-type natriuretic peptide
HF
heart failure
LV
left ventricular
N-BNP
N-terminal brain natriuretic peptide

Cited by (0)

This work was supported by the Health Research Council of New Zealand and the National Heart Foundation of New Zealand. Triage BNP test strips and analyser were provided by Biosite Diagnostics. Dr. Gottlieb C. Friesinger, II acted as Guest Editor for this manuscript. John Lainchbury holds a National Heart Foundation Senior Fellowship. Mark Richards holds the National Heart Foundation Chair of Cardiovascular Studies.