Original contributionMetered dose inhaler salbutamol treatment of asthma in the ED: Comparison of two doses with plasma levels
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Cited by (36)
Targeting mucus barrier in respiratory diseases by chemically modified advanced delivery systems
2022, Chemico-Biological InteractionsCitation Excerpt :The delivery of salbutamol via pressurized metered-dose inhaler and dry powder inhaler ensures a targeted delivery and high local drug concentration with a minimal systemic exposure [53]. However, salbutamol shows a prompt absorption to the systemic circulation in 10–15 min of administration via metered-dose inhaler [54]. High membrane permeability and water solubility of salbutamol lowers the drug duration and decreases the local concentration of the drug at the deliberated site.
Tremor and β <inf>2</inf>-adrenergic agents: Is it a real clinical problem?
2012, Pulmonary Pharmacology and TherapeuticsCitation Excerpt :Although β2-adrenergic agonists have low oral bioavailability, because of a high first-pass metabolism, if a sufficiently high dose is given, systemic activity can easily be demonstrated [70]. Generally, an increase of the dose produces a nonsignificantly slightly better therapeutic response but with greater adverse effects, probably related to higher β2-adrenergic agonist concentration [71]. Therefore, measurement of plasma β2-adrenergic agonist concentration is important for predicting the possibility of adverse events, but not therapeutic effects, due to exposure of airways β2-adrenoceptors to high local concentrations of β2-adrenergic agonist compared with the low serum levels in the periphery [72].
Severe acute asthma: Its management in emergency visits and intensive care
2006, Medicina IntensivaComparison between nebulized adrenaline and β<inf>2</inf> agonists for the treatment of acute asthma. a meta-analysis of randomized trials
2006, American Journal of Emergency MedicineDrug-induced tremors
2005, Lancet NeurologyCitation Excerpt :In large clinical trials, 7–20% of patients complained of tremor due to inhaled salbutamol with similar numbers of patients complaining of tremor due to isoprenaline (14%).79,80 Tremor associated with β2-adrenergic agonists is dose-related81,82 and may occur more commonly with oral dosing. Salmeterol, a β2-adrenergic agonist with a long half-life, is associated with tremor in 1·7% of patients chronically treated with 50 μg twice daily, although 5·7% of patients receiving a single dose of 100 μg salmeterol reported tremor.83
Acute asthma in adults: A review
2004, ChestCitation Excerpt :However, the resulting fall in Pao2 is small, of short duration, and generally of negligible significance. Available data about the use of high doses of β2-agonists support the concept that treatment of patients with AA with albuterol, 2.4 mg/h (four puffs at 10-min intervals by pMDI and spacer) or 2.5 mg every 20 min by nebulization, produces satisfactory bronchodilation, low serum concentration, and minimal side effects.7778138139150 In some patients with particularly severe conditions, it may be necessary to increase the dose to one or more puffs every 10 to 20 s.