Chest
Selected ReportsNoncardiogenic Pulmonary Edema Complicating Massive Verapamil Overdose
Section snippets
Case Report
A 27-year-old healthy woman was brought to the hospital 5 h after ingesting 15, 120-mg verapamil tablets (total of 1,800 mg Calan, G.D. Searle & Company, Chicago), 4 g of ibuprofen, and 10 tablets of a combination of acetaminophen, butalbital, and caffeine (Fioricet, Sandoz Pharmaceuticals Corporation, East Hanover, NJ). She was alert and oriented; the systolic BP was 70 mm Hg; pulse, 62 beats per minute; and respirations, 24 breaths per minute. The pupils were equal and responsive, and
Discussion
This patient demonstrates a case of noncardiogenic pulmonary edema after massive ingestion of verapamil. Noncardiogenic pulmonary edema was documented by bilateral diffuse pulmonary infiltrates on a chest radiograph with normal pulmonary capillary wedge pressure and thermodilution cardiac output. The signs and symptoms of noncardiogenic pulmonary edema resolved with conservative management and assisted ventilation for 72 h.
There appear to be several potential etiologies of this patient's
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59 - Lung Injury Caused by Pharmacologic Agents
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2007, Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose, Fourth EditionLung Injury Caused by Pharmacologic Agents
2006, Kendig's Disorders of the Respiratory Tract in ChildrenLymphocytic intracellular calcium in a patient with complicated verapamil overdose
2000, American Journal of the Medical SciencesThe diabetogenic effects of acute verapamil poisoning
1997, Toxicology and Applied Pharmacology