Chest
Clinical InvestigationsInfluence of Infused Adenosine on Bronchial Tone and Bronchial Reactivity in Asthma
Section snippets
Patients
Seven nonsmoking subjects (three women) with a mean age of 35 ± 5 years (range 21 to 56 years), who had bronchial asthma according to the definition of the American Thoracic Society,15 participated in the study. Four had a verified allergy, and all patients had verified bronchial hyperreactivity confirmed by a pretrial bronchial histamine provocation test (PC20 FEV1, ie, the concentration of histamine that yields a reduction in FEV1 by 20 percent of the basal value, was 0.93 ±0.30 mg/ml, range
RESULTS
All patients were in a stable phase without any symptom of asthma at the time of the trial, and basal PEF (ie, the lowest basal pre-challenge value for the two days) was 77 ± 5 percent (range 66 to 98 percent) of predicted value.16 There was no significant intraindividual difference in basal lung function when the two trial days were compared. Basal PEF and Sgaw are shown in Table 1. The intraindividual difference in PEF was 4.1 ± 1.1 percent; in Sgaw, 26.3 ± 8.5 percent between the two days.
DISCUSSION
All patients were free from asthmatic symptoms at the time of the trial with PEF>66 percent of predicted value. There was no difference in lung function between the days, which makes the two days comparable.
In previous studies, inhaled adenosine (but not guanosine) in high concentrations has been found to be a bronchoconstrictor in asthmatic patients, but not in healthy subjects.7 In vitro, in guinea pig tracheal preparations, adenosine increased basal smooth muscle tension in a dose-dependent
ACKNOWLEDGMENTS
The authors thank Assistant Professor Sture Bevegård for access to laboratory facilities and Caroline Angleryd, Berith Nilsson and Helene Johansson for expert technical assistance. Supported by grants from the Swedish National Association against Heart and Chest Diseases, the Swedish Medical Research Council (7485) and the Tore Wiberg Foundation.
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2007, Journal of Nuclear CardiologyCitation Excerpt :The results of this study indicate that the effect of intravenously infused adenosine is also concentration-dependent, with bronchoconstriction being more likely to occur at high infusion rates (≥100 μg · kg−1 · min−1). Larsson and Sollevi22 had already shown that adenosine infused at up to 50 μg · kg−1 · min−1 for 6 minutes had no effect on the caliber of the airways of asthmatic patients with proven bronchial hyperreactivity. The current study also suggests that exacerbation or late bronchoconstriction after discontinuation of the adenosine infusion is unlikely.
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2001, Medical Clinics of North AmericaCitation Excerpt :Dipyridamole potentiates the effect of adenosine,43 whereas methylxanthine derivatives, such as theophylline, antagonize its effects completely. Asthmatic patients may develop bronchospasm with adenosine, which is a relative contraindication to its use.40 Heart transplant recipients have denervation supersensitivity to adenosine.19
Elevated circulating adenosine level potentiates antigen-induced immediate bronchospasm and bronchoconstrictor mediator release in sensitized guinea pigs
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1994, The Journal of PediatricsAdenosine and the treatment of supraventricular tachycardia
1992, The American Journal of Medicine
Manuscript received February 16; revision accepted June 1.