Abstract
We performed a 7-year registry-based retrospective study. We included 1365 infants younger than 3 months of age with fever without a source; 81 (5.9%) had <5000 leukocytes/mm(3). Among the 1021 well-appearing 29- to 90-day-old infants, prevalence of serious bacterial infection (SBI) was 13.8% for those with a normal white blood cell count, 6.8% for those with leukopenia (odds ratio, 0.45), and 36.6% for those with leukocytosis (odds ratio, 3.59). None of the 9 well-appearing febrile neonates with leukopenia developed an SBI. Leukopenia, in well-appearing young febrile infants, should not be considered as an SBI risk factor.
MeSH terms
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Bacterial Infections / blood
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Bacterial Infections / diagnosis*
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Bacterial Infections / epidemiology*
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Bacterial Infections / microbiology
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Cross-Sectional Studies
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Escherichia coli Infections / diagnosis
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Escherichia coli Infections / epidemiology
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Escherichia coli Infections / microbiology
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Fever / epidemiology*
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Fever / etiology
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Humans
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Infant, Newborn
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Leukocyte Count
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Leukocytosis / blood
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Leukocytosis / diagnosis
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Leukocytosis / epidemiology
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Leukopenia / blood
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Leukopenia / diagnosis
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Leukopenia / epidemiology*
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Prevalence
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Risk Factors
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Streptococcal Infections / diagnosis
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Streptococcal Infections / epidemiology
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Streptococcal Infections / microbiology