Abstract
In a prospective, controlled, and randomized study, we compared the outcome of 101 Bell's palsy patients treated with acyclovir (54 patients) or prednisone (47 patients). The acyclovir dosage was 2400 mg (800 mg three times a day) for 10 days, and prednisone was given as a single daily dose of 1 mg/kg of body weight for 10 days and tapered to 0 over the next 6 days. Minimum follow-up was 3 months in all patients. Patients in the prednisone group had better clinical recovery than those treated with acyclovir. Less degree of neural degeneration was observed in the prednisone group compared with acyclovir patients. The incidence of sequelae was the same in both groups. According to these results, in a 10-day treatment cycle acyclovir given 800 mg three times is not as useful as prednisone given 1 mg/kg of body weight once a day in patients with idiopathic facial nerve paralysis.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
MeSH terms
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Acyclovir / administration & dosage
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Acyclovir / adverse effects
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Acyclovir / therapeutic use*
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Analysis of Variance
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Anti-Inflammatory Agents / administration & dosage
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Anti-Inflammatory Agents / adverse effects
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Anti-Inflammatory Agents / therapeutic use*
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Antiviral Agents / administration & dosage
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Antiviral Agents / adverse effects
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Antiviral Agents / therapeutic use*
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Body Weight
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Drug Administration Schedule
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Facial Nerve / pathology
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Facial Nerve / physiopathology
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Facial Paralysis / drug therapy*
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Facial Paralysis / pathology
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Facial Paralysis / physiopathology
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Female
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Follow-Up Studies
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Glucocorticoids / administration & dosage
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Glucocorticoids / adverse effects
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Glucocorticoids / therapeutic use
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Humans
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Incidence
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Male
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Middle Aged
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Nerve Degeneration / pathology
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Nerve Degeneration / physiopathology
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Prednisone / administration & dosage
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Prednisone / adverse effects
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Prednisone / therapeutic use*
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Prospective Studies
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Treatment Outcome
Substances
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Anti-Inflammatory Agents
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Antiviral Agents
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Glucocorticoids
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Prednisone
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Acyclovir