Pulmonary and systemic arterial hypertension are associated with profound alterations in
Ca2+ homeostasis and smooth muscle cell proliferation. A novel class of non-selective …

In this review, the pathological alteration and clinical relevance of voltage-gated K+ (Kv)
channels and their specific regulation by protein kinase-dependent signaling in vascular …

Despite improved understanding of the pathobiology of pulmonary arterial hypertension
(PAH), it remains a severe and progressive disease, usually culminating in right heart …

Lung disease is a major cause of death in the United States, with current therapeutic
approaches serving only to manage symptoms. The most common chronic and life …

Despite therapeutic advancement, pulmonary disease still remains a major cause of
morbidity and mortality around the world. Opportunities to study human lung disease either …

Platelet-derived growth factor (PDGF) and its receptor are known to be substantially
elevated in lung tissues and pulmonary arterial smooth muscle cells (PASMC) isolated from …

Rationale: Alveolar epithelial cell (AEC) injury and dysregulated repair are implicated in the
pathogenesis of pulmonary fibrosis. Endoplasmic reticulum (ER) stress in AEC has been …

Summary X-linked Severe Combined Immunodeficiency (SCID-X1) is a genetic disease that
leaves newborns at high risk of serious infection and a predicted life span of less than 1 year …

Background—Adenylyl cyclases (ACs) are a family of effector molecules for G-protein–
coupled receptors. The 2 ACs most abundantly expressed in cardiac myocytes are types 5 …

Motile cilia are characterized by dynein motor units, which preassemble in the cytoplasm
before trafficking into the cilia. Proteins required for dynein preassembly were discovered by …