User profiles for "author:Alexis Leal"

Alexis D Leal

University of Colorado School of Medicine
Verified email at cuanschutz.edu
Cited by 938

[HTML][HTML] Non-V600BRAF mutations define a clinically distinct molecular subtype of metastatic colorectal cancer

JC Jones, LA Renfro, HO Al-Shamsi… - Journal of Clinical …, 2017 - ncbi.nlm.nih.gov
Purpose Molecular diagnostic testing has become an integral part of the evaluation of
patients with metastatic colorectal cancer (CRC). Expanded mutational testing, such as next …

Clinical development of immunotherapy for deficient mismatch repair colorectal cancer

J Thomas, A Leal, MJ Overman - Clinical colorectal cancer, 2020 - Elsevier
Colorectal cancer (CRC) is the second most common cause of cancer-related death in the
United States. Despite excellent prognosis for early stage disease, 5-year survival rates in …

Syphilis management in pregnancy: a review of guideline recommendations from countries around the world

T Trinh, AF Leal, MB Mello, MM Taylor… - Sexual and …, 2019 - Taylor & Francis
Guidelines can help healthcare practitioners manage syphilis in pregnancy and prevent
perinatal death or disability. We conducted systematic reviews to locate guidance …

[HTML][HTML] Lymph-node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: the phase 1 AMPLIFY-201 trial

S Pant, ZA Wainberg, CD Weekes, M Furqan… - Nature medicine, 2024 - nature.com
Pancreatic and colorectal cancers are often KRAS mutated and are incurable when tumor
DNA or protein persists or recurs after curative intent therapy. Cancer vaccine ELI-002 2P …

[HTML][HTML] NCCTG N08CA (Alliance): The use of glutathione for prevention of paclitaxel/carboplatin induced peripheral neuropathy: A phase III randomized, double-blind …

AD Leal, R Qin, PJ Atherton, P Haluska Jr, RJ Behrens… - Cancer, 2014 - ncbi.nlm.nih.gov
Background Chemotherapy-induced peripheral neuropathy (CIPN) is a significant side effect
of taxane and platinum based chemotherapy. Several studies have supported the potential …

North Central Cancer Treatment Group/Alliance trial N08CA—the use of glutathione for prevention of paclitaxel/carboplatin‐induced peripheral neuropathy: A phase 3 …

AD Leal, R Qin, PJ Atherton, P Haluska, RJ Behrens… - Cancer, 2014 - Wiley Online Library
BACKGROUND Chemotherapy‐induced peripheral neuropathy (CIPN) is a significant side
effect of taxane and platinum‐based chemotherapy. Several studies have supported the …

[HTML][HTML] ATM kinase inhibitor AZD0156 in combination with irinotecan and 5-fluorouracil in preclinical models of colorectal cancer

SL Davis, SJ Hartman, SM Bagby, M Schlaepfer… - BMC cancer, 2022 - Springer
Background AZD0156 is an oral inhibitor of ATM, a serine threonine kinase that plays a key
role in DNA damage response (DDR) associated with double-strand breaks. Topoisomerase …

Anthropometric, medical history and lifestyle risk factors for myeloproliferative neoplasms in the Iowa Women's Health Study cohort

AD Leal, CA Thompson, AH Wang… - … journal of cancer, 2014 - Wiley Online Library
Classical myeloproliferative neoplasms (MPNs) are composed of essential thrombocythemia
(ET), polycythemia vera (PV) and myelofibrosis (MF), the etiology of which is largely …

[HTML][HTML] Cabozantinib sensitizes microsatellite stable colorectal cancer to immune checkpoint blockade by immune modulation in human immune system mouse …

J Lang, AD Leal, JA Marín-Jiménez, SJ Hartman… - Frontiers in …, 2022 - frontiersin.org
Immune checkpoint inhibitors have been found to be effective in metastatic MSI-high
colorectal cancers (CRC), however, have no efficacy in microsatellite stable (MSS) cancers …

[HTML][HTML] WEE1 inhibition in combination with targeted agents and standard chemotherapy in preclinical models of pancreatic ductal adenocarcinoma

SJ Hartman, SM Bagby, BW Yacob… - Frontiers in …, 2021 - frontiersin.org
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer with high incidences of
p53 mutations. AZD1775 (adavosertib, previously MK-1775) is a small molecule WEE1 …