Iron metabolism, free radicals, and oxidative injury

J Emerit, C Beaumont, F Trivin - Biomedicine & pharmacotherapy, 2001 - Elsevier
Iron has the capacity to accept and donate electrons readily. This capability makes it
physiologically essential, as a useful component of cytochromes and oxygen-binding …

Function and regulation of transferrin and ferritin.

P Ponka, C Beaumont, DR Richardson - Seminars in hematology, 1998 - europepmc.org
Iron represents a paradox for living systems by being essential for a wide variety of
metabolic processes (oxygen transport, electron transport, DNA synthesis, etc) but also …

The Edmonton Symptom Assessment System: a 15-year retrospective review of validation studies (1991–2006)

…, S Watanabe, C Beaumont - Palliative …, 2008 - journals.sagepub.com
Introduction: The purpose of this review was to identify and critique validation studies
focusing on the Edmonton Symptom Assessment System (ESAS), a commonly used …

Himalayan tectonics explained by extrusion of a low-viscosity crustal channel coupled to focused surface denudation

C Beaumont, RA Jamieson, MH Nguyen, B Lee - Nature, 2001 - nature.com
Abstract Recent interpretations of Himalayan–Tibetan tectonics have proposed that channel
flow in the middle to lower crust can explain outward growth of the Tibetan plateau,,, and that …

[HTML][HTML] The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation

…, X Bigard, I Devaux, C Beaumont… - The Journal of …, 2002 - Am Soc Clin Investig
The present study was aimed at determining whether hepcidin, a recently identified peptide
involved in iron metabolism, plays a role in conditions associated with both iron overload …

Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice

…, M Bennoun, I Devaux, C Beaumont… - Proceedings of the …, 2001 - National Acad Sciences
We previously reported the disruption of the murine gene encoding the transcription factor
USF2 and its consequences on glucose-dependent gene regulation in the liver. We report …

Foreland basins

C Beaumont - Geophysical Journal International, 1981 - academic.oup.com
The characteristic pattern of the subsidence, deformation, uplift and erosion of foreland
basins, or exogeosynclines, has long been recognized by geologists as an integral part of …

[HTML][HTML] Ferritin heavy chain upregulation by NF-κB inhibits TNFα-induced apoptosis by suppressing reactive oxygen species

…, S Jayawardena, E De Smaele, R Cong, C Beaumont… - Cell, 2004 - cell.com
During inflammation, NF-κB transcription factors antagonize apoptosis induced by tumor
necrosis factor (TNF) α. This antiapoptotic activity of NF-κB involves suppressing the …

Severe iron deficiency anemia in transgenic mice expressing liver hepcidin

…, A Porteu, S Mativet, C Beaumont… - Proceedings of the …, 2002 - National Acad Sciences
We recently reported the hemochromatosis-like phenotype observed in our Usf2 knockout
mice. In these mice, as in murine models of hemochromatosis and patients with hereditary …

Tilting of continental interiors by the dynamical effects of subduction

JX Mitrovica, C Beaumont, GT Jarvis - Tectonics, 1989 - Wiley Online Library
A mechanism is proposed to explain epeirogenic motions of craton interiors in terms of the
response of the lithosphere to subduction. The effects of changes in sea level are …