The breadth of structure and function displayed by the molecules of biology is remarkable.
Considering that there are only three major biopolymer backbones (proteins, ribonucleic …

Abstract The Gene Ontology (GO) knowledgebase (http://geneontology. org) is a
comprehensive resource concerning the functions of genes and gene products (proteins …

Today's children and adolescents are immersed in both traditional and new forms of digital
media. Research on traditional media, such as television, has identified health concerns and …

Genomic sequencing has made it clear that a large fraction of the genes specifying the core
biological functions are shared by all eukaryotes. Knowledge of the biological role of such …

Mitochondria are complex organelles whose dysfunction underlies a broad spectrum of
human diseases. Identifying all of the proteins resident in this organelle and understanding …

Systematic mapping of protein–protein interactions, or 'interactome'mapping, was initiated in
model organisms, starting with defined biological processes, and then expanding to the …

An attempt is made to correlate in a unified picture the features of the empirical evidence on
nuclear constitution, some of which appear to require for their explanation the liquid drop …

The tumor growth suppressor WAF1/CIP1 was recently shown to be induced by p53 and to
be a potent inhibitor of cyclin-dependent kinases. In the present studies, we sought to …

The problem of defining and classifying power system stability has been addressed by
several previous CIGRE and IEEE Task Force reports. These earlier efforts, however, do not …

Oncogenic mutations in the serine/threonine kinase B-RAF (also known as BRAF) are found
in 50–70% of malignant melanomas. Pre-clinical studies have demonstrated that the B-RAF …