Aberrant DNA methylation of CpG islands has been widely observed in human colorectal
tumors and is associated with gene silencing when it occurs in promoter areas. A subset of …

Background Compared with open resection, laparoscopic resection of rectal cancers is
associated with improved short-term outcomes, but high-level evidence showing similar long …

Context.—Colorectal cancer is a heterogeneous disease entity with 3 molecular
carcinogenesis pathways and 2 morphologic multistep pathways. Right-sided colon cancers …

Colorectal cancers (CRCs) with a high level of microsatellite instability (MSI-H) are
clinicopathologically distinct tumors characterized by predominance in females, proximal …

Flavonoids are highly diversified plant pigments that are present in a wide range of fruits,
vegetables, nuts, and beverages. They are regularly consumed in the human diet and have …

To determine the methylation profile of multiple tumor-related genes during multistep
hepatocarcinogenesis, we investigated the methylation status of CpG islands of 9 genes …

CpG island methylation is an important mechanism for inactivating the genes involved in
tumorigenesis. Gastric carcinoma (GC) is one of the tumors that exhibits a high frequency of …

Background Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis. The high
risk of recurrence following surgical resection provides the rationale for adjuvant therapy …

To date, several reports have been published about CpG island methylation of various
genes in prostate cancer. However, most of these studies have focused on cancer tissue …

Accumulating evidence has identified a mechanism potentially responsible for the
inactivation of tumor suppressor genes, namely transcriptional silencing by aberrant …