The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing worldwide. In
some patients with NAFLD, isolated steatosis can progress to advanced stages with non …

Type 2 diabetes and cardiovascular disease represent a serious threat to the health of the
population worldwide. Although overall adiposity and particularly visceral adiposity are …

Diabetes mellitus type 2 is a world-wide growing health problem affecting more than 150
million people at the beginning of the new millennium. It is believed that this number will …

Background Obesity represents a risk factor for insulin resistance, type 2 diabetes mellitus,
and atherosclerosis. In addition, for any given amount of total body fat, an excess of visceral …

Activation of the transcription factor nuclear factor-κB (NF-κB) has been suggested to
participate in chronic disorders, such as diabetes and its complications. In contrast to the …

Metabolomic discovery of biomarkers of type 2 diabetes (T2D) risk may reveal etiological
pathways and help to identify individuals at risk for disease. We prospectively investigated …

Obesity has become a worldwide epidemic that poses substantial health problems for both
individuals and society. However, a proportion of obese individuals might not be at an …

Insulin resistance plays an important role in the pathogenesis of type 2 diabetes; however,
the multiple mechanisms causing insulin resistance are not yet fully understood. The aim of …

Cancer control by adaptive immunity involves a number of defined death,,,,,,, and clearance,,
mechanisms. However, efficient inhibition of exponential cancer growth by T cells and …

OBJECTIVE—The α2-Heremans-Schmid glycoprotein (AHSG; fetuin-A in animals) impairs
insulin signaling in vitro and in rodents. Whether AHSG is associated with insulin resistance …