User profiles for "author:James Collins"

James J Collins

MIT; Wyss Institute, Harvard; Broad Institute of MIT & Harvard
Verified email at mit.edu
Cited by 125823

How antibiotics kill bacteria: from targets to networks

MA Kohanski, DJ Dwyer, JJ Collins - Nature Reviews Microbiology, 2010 - nature.com
Antibiotic drug–target interactions, and their respective direct effects, are generally well
characterized. By contrast, the bacterial responses to antibiotic drug treatments that …

Stochasticity in gene expression: from theories to phenotypes

M Kaern, TC Elston, WJ Blake, JJ Collins - Nature Reviews Genetics, 2005 - nature.com
Genetically identical cells exposed to the same environmental conditions can show
significant variation in molecular content and marked differences in phenotypic …

[HTML][HTML] End-to-end design of wearable sensors

HC Ates, PQ Nguyen, L Gonzalez-Macia… - Nature Reviews …, 2022 - nature.com
Wearable devices provide an alternative pathway to clinical diagnostics by exploiting
various physical, chemical and biological sensors to mine physiological (biophysical and/or …

[HTML][HTML] Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic

DF Santomauro, AMM Herrera, J Shadid, P Zheng… - The Lancet, 2021 - thelancet.com
Background Before 2020, mental disorders were leading causes of the global health-related
burden, with depressive and anxiety disorders being leading contributors to this burden. The …

[HTML][HTML] Estimating excess mortality due to the COVID-19 pandemic: a systematic analysis of COVID-19-related mortality, 2020–21

H Wang, KR Paulson, SA Pease, S Watson, H Comfort… - The Lancet, 2022 - thelancet.com
Background Mortality statistics are fundamental to public health decision making. Mortality
varies by time and location, and its measurement is affected by well known biases that have …

Construction of a genetic toggle switch in Escherichia coli

TS Gardner, CR Cantor, JJ Collins - Nature, 2000 - nature.com
It has been proposed that gene-regulatory circuits with virtually any desired property can be
constructed from networks of simple regulatory elements. These properties, which include …

A practical method for calculating largest Lyapunov exponents from small data sets

MT Rosenstein, JJ Collins, CJ De Luca - Physica D: Nonlinear Phenomena, 1993 - Elsevier
Detecting the presence of chaos in a dynamical system is an important problem that is
solved by measuring the largest Lyapunov exponent. Lyapunov exponents quantify the …

[PDF][PDF] Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA

L Warren, PD Manos, T Ahfeldt, YH Loh, H Li, F Lau… - Cell stem cell, 2010 - cell.com
Clinical application of induced pluripotent stem cells (iPSCs) is limited by the low efficiency
of iPSC derivation and the fact that most protocols modify the genome to effect cellular …

[BOOK][B] Global positioning system: theory and practice

B Hofmann-Wellenhof, H Lichtenegger, J Collins - 2012 - books.google.com
This book is dedicated to Dr. Benjamin William Remondi for many reasons. The project of
writing a Global Positioning System (GPS) book was con ceived in April 1988 at a GPS …

[HTML][HTML] A common mechanism of cellular death induced by bactericidal antibiotics

MA Kohanski, DJ Dwyer, B Hayete, CA Lawrence… - Cell, 2007 - cell.com
Antibiotic mode-of-action classification is based upon drug-target interaction and whether
the resultant inhibition of cellular function is lethal to bacteria. Here we show that the three …