User profiles for "author:Jesse Smith"

Jesse J Smith

- Verified email at as-photonics.com - Cited by 1306

Jesse M. Smith

- Verified email at wmich.edu - Cited by 1131

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

JC Milne, PD Lambert, S Schenk, DP Carney, JJ Smith… - Nature, 2007 - nature.com
Calorie restriction extends lifespan and produces a metabolic profile desirable for treating
diseases of ageing such as type 2 diabetes,. SIRT1, an NAD+-dependent deacetylase, is a …

[PDF][PDF] Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor

SR Daigle, EJ Olhava, CA Therkelsen, CR Majer… - Cancer cell, 2011 - cell.com
Mislocated enzymatic activity of DOT1L has been proposed as a driver of leukemogenesis in
mixed lineage leukemia (MLL). The characterization of EPZ004777, a potent, selective …

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

SK Knutson, TJ Wigle, NM Warholic… - Nature chemical …, 2012 - nature.com
EZH2 catalyzes trimethylation of histone H3 lysine 27 (H3K27). Point mutations of EZH2 at
Tyr641 and Ala677 occur in subpopulations of non-Hodgkin's lymphoma, where they drive …

Mode instability in high power fiber amplifiers

AV Smith, JJ Smith - Optics express, 2011 - opg.optica.org
Mode instability in high power fiber amplifiers clickable element to expand a topic LOGIN OR
CREATE ACCOUNT PRISM SUBMISSION This website uses cookies to deliver some of our …

Selective Inhibition of EZH2 by EPZ-6438 Leads to Potent Antitumor Activity in EZH2-Mutant Non-Hodgkin Lymphoma

SK Knutson, S Kawano, Y Minoshima… - Molecular cancer …, 2014 - AACR
Mutations within the catalytic domain of the histone methyltransferase EZH2 have been
identified in subsets of patients with non-Hodgkin lymphoma (NHL). These genetic …

A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

E Chan-Penebre, KG Kuplast, CR Majer… - Nature chemical …, 2015 - nature.com
Abstract Protein arginine methyltransferase-5 (PRMT5) is reported to have a role in diverse
cellular processes, including tumorigenesis, and its overexpression is observed in cell lines …

Mapping religion's other: A review of the study of nonreligion and secularity

JM Smith, RT Cragun - Journal for the Scientific Study of …, 2019 - Wiley Online Library
In this article, we review the research literature on nonreligion, secularity, the nones, and
other forms of “religion's other.” As a relatively new area of sustained and still growing …

SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes

T Yoshizaki, JC Milne, T Imamura… - … and cellular biology, 2009 - Taylor & Francis
SIRT1 is a prominent member of a family of NAD+-dependent enzymes and affects a variety
of cellular functions ranging from gene silencing, regulation of the cell cycle and apoptosis …

Ice Core Records of Atmospheric CO2 Around the Last Three Glacial Terminations

H Fischer, M Wahlen, J Smith, D Mastroianni, B Deck - Science, 1999 - science.org
Air trapped in bubbles in polar ice cores constitutes an archive for the reconstruction of the
global carbon cycle and the relation between greenhouse gases and climate in the past …

[HTML][HTML] Apoptosis induction by caspase-8 is amplified through the mitochondrial release of cytochrome c

T Kuwana, JJ Smith, M Muzio, V Dixit… - Journal of Biological …, 1998 - ASBMB
Apoptosis often involves the release of cytochrome c from mitochondria, leading to caspase
activation. However, in apoptosis mediated by CD95 (Fas/APO-1), caspase-8 …