The Wnt/β-catenin signaling pathway is critical for normal mammalian development, the
specification of epidermal cells and neoplastic transformation of intestinal epithelium …

Mass gatherings are events characterized by “the concentration of people at a specific
location for a specific purpose over a set period of time that have the potential to strain the …

The Wnt/β-catenin signaling pathway controls cell fate and neoplastic transformation.
Expression of an endogenous stabilized β-catenin (ΔE3 β-catenin) in mammary epithelium …

Background It is well known that the prognosis of castration-resistant prostate cancer
(CRPC) is poor, and several immunotherapeutic strategies have been applied to the clinical …

Objectives: The aim of this study is to evaluate the efficacy and safety of intrarenal bacillus
Calmette–Guérin (BCG) instillation as a treatment for transitional cell carcinoma in situ (CIS) …

Background Accidental hypothermia (AH) has higher incidence and mortality in geriatric
populations. Japan has a rapidly ageing population, and little is known about the …

Objectives To evaluate the efficacy and safety of cabozantinib, through a bridging study to
METEOR, in Japanese patients with advanced renal cell carcinoma who had progressed …

Objectives To clarify treatment patterns and outcomes for patients with unresectable or
metastatic renal cell carcinoma in the molecular target therapy era in Japan. Methods A …

Background In a phase III clinical trial, CheckMate 025, treatment of metastatic renal cell
carcinoma (mRCC) with nivolumab demonstrated superior efficacy over everolimus …

Background Anti-PD-1 antibodies are widely used for cancer treatment including advanced
renal cell carcinoma (RCC). However, their therapeutic and adverse effects vary among …