During the past 20 years contributions from many laboratories have led to the development
of isolation procedures, delineation of primary structures, and more recently, to the …

With the recent publication of regulatory guidelines from both the FDA and the CPMP
addressing the investigation of immunotoxicity of new chemical entities has come the …

Resilience has been defined as a dynamic process of maintaining positive adaptation and
effective coping strategies in the face of adversity (Luthar et al. 2000). Although most …

Constitutive JAK2 activation in hematopoietic cells by the JAK2V617F mutation recapitulates
myeloproliferative neoplasm (MPN) phenotypes in mice, establishing JAK2 inhibition as a …

Inhibiting signal transduction induced by inflammatory cytokines offers a new approach for
the treatment of autoimmune diseases such as rheumatoid arthritis. Kinase inhibitors have …

Malignant tumors arise, in part, because the immune system does not adequately recognize
and destroy them. Expression of indoleamine-2, 3-dioxygenase (IDO; IDO1), a rate-limiting …

An efficient implementation of generalized predictive control using a multilayer feedforward
neural network as the plant's nonlinear model is presented. By using Newton-Raphson as …

The motion of the free surface of a viscous droplet is investigated. By using lubrication theory
a model is developed for the motion of the free surface which includes both the effect of slip …

This paper describes some preliminary results of the cooperative effort between SACLANT
Undersea Research Centre and Harvard University in the development of a regional …

We develop and illustrate an efficient but rigorous methodology that predicts the time-
optimal paths of ocean vehicles in continuous dynamic flows. The goal is to best utilize or …