User profiles for "author:Pedro Zapater"

PEDRO ZAPATER HERNANDEZ

Professor of Pharmacology, University Miguel Hernandez
Verified email at goumh.umh.es
Cited by 7551

[HTML][HTML] Aggressive or moderate fluid resuscitation in acute pancreatitis

E de-Madaria, JL Buxbaum… - … England Journal of …, 2022 - Mass Medical Soc
Background Early aggressive hydration is widely recommended for the management of
acute pancreatitis, but evidence for this practice is limited. Methods At 18 centers, we …

Detection and identification of bacterial DNA in patients with cirrhosis and culture-negative, nonneutrocytic ascites

J Such, R Francés, C Munoz, P Zapater, JA Casellas… - Hepatology, 2002 - Elsevier
The current pathogenic theory of spontaneous bacterial peritonitis (SBP) in patients with
cirrhosis and ascites suggests that repeated episodes of bacterial translocation (BT) from …

Mismatch repair status in the prediction of benefit from adjuvant fluorouracil chemotherapy in colorectal cancer

R Jover, P Zapater, A Castells, X Llor, M Andreu… - Gut, 2006 - gut.bmj.com
Aim: Some retrospective studies have shown a lack of benefit of 5-fluorouracil (5-FU)
adjuvant chemotherapy in patients with mismatch repair (MMR) deficient colorectal cancer …

Risk of cancer in cases of suspected lynch syndrome without germline mutation

M Rodríguez–Soler, L Pérez–Carbonell, C Guarinos… - Gastroenterology, 2013 - Elsevier
BACKGROUND & AIMS: Colorectal cancers (CRCs) with microsatellite instability (MSI) and
a mismatch repair (MMR) immunohistochemical deficit without hypermethylation of the …

The efficacy of adjuvant chemotherapy with 5-fluorouracil in colorectal cancer depends on the mismatch repair status

R Jover, P Zapater, A Castells, X Llor, M Andreu… - European journal of …, 2009 - Elsevier
AIMS: The aim of this study is to evaluate if mismatch repair (MMR) defective colorectal
cancer has a different response to adjuvant 5-fluorouracil (5-FU) chemotherapy in a cohort …

5-Fluorouracil adjuvant chemotherapy does not increase survival in patients with CpG island methylator phenotype colorectal cancer

R Jover, TP Nguyen, L Pérez–Carbonell, P Zapater… - Gastroenterology, 2011 - Elsevier
BACKGROUND & AIMS: 5-Fluorouracil (5-FU)–based adjuvant chemotherapy does not
increase survival times of patients with colorectal tumors with microsatellite instability. We …

[PDF][PDF] Serum and ascitic fluid bacterial DNA: a new independent prognostic factor in noninfected patients with cirrhosis

P Zapater, R Francés, JM González‐Navajas… - …, 2008 - Wiley Online Library
We tested the hypothesis that the presence of bacterial DNA (bactDNA) in ascitic fluid and
serum is associated with decreased survival in patients with cirrhosis. In a prospective …

[PDF][PDF] Bacterial DNA in patients with cirrhosis and noninfected ascites mimics the soluble immune response established in patients with spontaneous bacterial …

R Francés, P Zapater, JM González‐Navajas… - …, 2008 - Wiley Online Library
Bacterial infections and severity of associated inflammatory reaction influence prognosis in
patients with advanced cirrhosis. We compared the innate immune response to bacterial …

Intestinal permeability is increased in patients with advanced cirrhosis.

S Pascual, J Such, A Esteban, P Zapater… - Hepato …, 2003 - europepmc.org
Results Lactulose/mannitol ratio was significantly higher in cirrhotic patients than in controls
(p= 0.03). This was more evident in end-stage cirrhosis. Patients with ascites, or …

[PDF][PDF] A sequential study of serum bacterial DNA in patients with advanced cirrhosis and ascites

R Francés, S Benlloch, P Zapater, JM González… - …, 2004 - Wiley Online Library
Bacterial translocation is currently considered the main pathogenic mechanism leading to
spontaneous bacterial peritonitis in patients with advanced cirrhosis and ascites. However …