Cardiovascular risk stratification in familial hypercholesterolaemia

M Sharifi, RD Rakhit, SE Humphries, D Nair - Heart, 2016 - heart.bmj.com
Familial hypercholesterolaemia (FH) is a common autosomal-dominant disorder in most
European countries. Patients with FH are characterised by a raised level of low-density …

[HTML][HTML] Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised …

DJ Hausenloy, RK Kharbanda, UK Møller, M Ramlall… - The Lancet, 2019 - thelancet.com
Background Remote ischaemic conditioning with transient ischaemia and reperfusion
applied to the arm has been shown to reduce myocardial infarct size in patients with ST …

Myocardial edema and prognosis in amyloidosis

T Kotecha, A Martinez-Naharro, TA Treibel… - Journal of the American …, 2018 - jacc.org
Background: Prognosis in light-chain (AL) and transthyretin (ATTR) amyloidosis is
influenced by cardiac involvement. ATTR amyloidosis has better prognosis than AL …

[HTML][HTML] Acute coronary syndromes

T Kotecha, RD Rakhit - Clinical Medicine, 2016 - ncbi.nlm.nih.gov
In the UK, there are over 80,000 admissions annually with acute coronary syndromes (ACS).
Management of ST-elevation myocardial infarction (STEMI) involves primary percutaneous …

Nitric oxide: an emerging role in cardioprotection?

RD Rakhit, MS Marber - Heart, 2001 - heart.bmj.com
Over a decade of research has shown nitric oxide (NO) to be a ubiquitous modulator of
biological phenomena from cell signal to eVector and from physiology to pathophysiology …

Risks and benefits of percutaneous coronary intervention in spontaneous coronary artery dissection

D Kotecha, M Garcia-Guimaraes, D Premawardhana… - Heart, 2021 - heart.bmj.com
Objective To investigate percutaneous coronary intervention (PCI) practice in an
international cohort of patients with spontaneous coronary artery dissection (SCAD). To …

Mitochondria as targets for nitric oxide–induced protection during simulated ischemia and reoxygenation in isolated neonatal cardiomyocytes

RD Rakhit, MH Mojet, MS Marber, MR Duchen - Circulation, 2001 - Am Heart Assoc
Background—As shown previously, exposure to NO donors initiates protective mechanisms
in cardiomyocytes that persist after removal of the donor, a form of pharmacological …

[HTML][HTML] All-optical rotational ultrasound imaging

RJ Colchester, C Little, G Dwyer, S Noimark… - Scientific Reports, 2019 - nature.com
Miniaturised high-resolution imaging devices are valuable for guiding minimally invasive
procedures such as vascular stent placements. Here, we present all-optical rotational B …

[HTML][HTML] Prospective comparison of novel dark blood late gadolinium enhancement with conventional bright blood imaging for the detection of scar

R Francis, P Kellman, T Kotecha, A Baggiano… - Journal of …, 2017 - Springer
Background Conventional bright blood late gadolinium enhancement (bright blood LGE)
imaging is a routine cardiovascular magnetic resonance (CMR) technique offering excellent …

Outcome of 1051 octogenarian patients with ST‐segment elevation myocardial infarction treated with primary percutaneous coronary intervention: observational …

DI Bromage, DA Jones, KS Rathod… - Journal of the …, 2016 - Am Heart Assoc
Background ST‐segment elevation myocardial infarction is increasingly common in
octogenarians, and optimal management in this cohort is uncertain. This study aimed to …