Abstract The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic
Shock 2020 (J-SSCG 2020), a Japanese-specific set of clinical practice guidelines for sepsis …

Expanding elderly populations are a major social challenge in advanced countries
worldwide and have led to a rapid increase in the number of elderly patients in intensive …

Epigenetic silencing is now recognized as a 'third pathway'in Knudson's model of tumor-
suppressor gene inactivation in cancer and can affect gene function without genetic …

Clouds and aerosols continue to contribute the largest uncertainty to estimates and
interpretations of the Earth's changing energy budget. This chapter focuses on process …

We report a method for studying global DNA methylation based on using bisulfite treatment
of DNA and simultaneous PCR of multiple DNA repetitive elements, such as Alu elements …

Grade II and III gliomas are generally slowly progressing brain cancers, many of which
eventually transform into more aggressive tumors. Despite recent findings of frequent …

Epigenetic silencing in cancer cells is mediated by at least two distinct histone modifications,
polycomb-based histone H3 lysine 27 trimethylation (H3K27triM) and H3K9 dimethylation …

Colon cancer has been viewed as the result of progressive accumulation of genetic and
epigenetic abnormalities. However, this view does not fully reflect the molecular …

Background: Sporadic colorectal cancers often arise from a region of cells characterized by
a “field defect” that has not been well defined molecularly. DNA methylation has been …

We evaluate black carbon (BC) model predictions from the AeroCom model intercomparison
project by considering the diversity among year 2000 model simulations and comparing …