Article Text

Transient lupus anticoagulant: an unusual cause of bruising in children
  1. A-K Anderson1,
  2. U Mohan1,
  3. R Liesner2
  1. 1Department of Paediatrics, Hemel Hempstead General Hospital, UK
  2. 2Department of Paediatric Haematology, Great Ormond Street Hospital, London, UK
  1. Correspondence to:
    Dr A-K Anderson, 20 Kendal Close, London SW9 6EW, UK;


A child presented with excessive bruising and prolonged activated partial thromboplastin time. Mixing studies in plasma were positive for phospholipid dependence of the anticoagulant, confirming a diagnosis of lupus anticoagulant. Factor II level was reduced. Laboratory findings normalised after three months, with spontaneous resolution of bruising. This case demonstrates a transient antiphospholipid antibody syndrome as a rare presentation of bleeding diathesis in a previously healthy child, and should be considered in children with new onset bruising and prolonged activated partial thromboplastin time.

  • lupus anticoagulant
  • coagulation
  • bleeding diathesis
  • aPTT, activated partial thromboplastin time
  • LA, lupus anticoagulant
  • APA, antiphospholipid antibody

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